Abstract
Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacteremia / etiology*
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology*
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Carbon-Sulfur Lyases
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Homoserine / analogs & derivatives*
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Homoserine / analysis
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Lactones / analysis
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Neisseria meningitidis / genetics
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Neisseria meningitidis / pathogenicity*
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Rats
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Rats, Wistar
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Virulence
Substances
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Bacterial Proteins
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Lactones
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N-octanoylhomoserine lactone
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Homoserine
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Carbon-Sulfur Lyases
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LuxS protein, Bacteria