Abstract
Stereoselective syntheses of (+/-)-epibatidine analogues 2, which contain the 8-azabicyclo [3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from 4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Analgesics, Non-Narcotic / chemical synthesis*
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Analgesics, Non-Narcotic / chemistry
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Animals
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Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
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Bridged Bicyclo Compounds, Heterocyclic / chemistry
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Catalysis
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Male
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Mice
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Mice, Inbred ICR
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Nicotinic Agonists / chemical synthesis*
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Nicotinic Agonists / chemistry
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Pain Measurement / drug effects
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Pyridines / chemical synthesis*
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Pyridines / chemistry
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Stereoisomerism
Substances
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Analgesics, Non-Narcotic
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Bridged Bicyclo Compounds, Heterocyclic
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Indicators and Reagents
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Nicotinic Agonists
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Pyridines
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epibatidine