Stereoselective syntheses of (+/-)-epibatidine analogues

Arch Pharm Res. 2002 Feb;25(1):45-8. doi: 10.1007/BF02975259.

Abstract

Stereoselective syntheses of (+/-)-epibatidine analogues 2, which contain the 8-azabicyclo [3.2.1]octane ring system, were achieved by using palladium-catalyzed cross-coupling reaction from 4 and the analgesic activity was tested by Mouse writhing antinociceptive assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Non-Narcotic / chemical synthesis*
  • Analgesics, Non-Narcotic / chemistry
  • Animals
  • Bridged Bicyclo Compounds, Heterocyclic / chemical synthesis*
  • Bridged Bicyclo Compounds, Heterocyclic / chemistry
  • Catalysis
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Male
  • Mice
  • Mice, Inbred ICR
  • Nicotinic Agonists / chemical synthesis*
  • Nicotinic Agonists / chemistry
  • Pain Measurement / drug effects
  • Pyridines / chemical synthesis*
  • Pyridines / chemistry
  • Stereoisomerism

Substances

  • Analgesics, Non-Narcotic
  • Bridged Bicyclo Compounds, Heterocyclic
  • Indicators and Reagents
  • Nicotinic Agonists
  • Pyridines
  • epibatidine