Abstract
Toxicity from intermediate-dose methotrexate (MTX) is unusual. A severely obese adolescent with acute lymphoblastic leukemia experienced significant, delayed nephrotoxicity from intermediate-dose MTX. Altered MTX disposition may occur as a consequence of other ingestions or conditions such as obesity. The use of radioisotope renography established the diagnosis and followed the resolution of the patient's MTX-induced nephrotoxicity.
MeSH terms
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Adolescent
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Antimetabolites, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic / adverse effects*
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Humans
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Kidney Diseases / chemically induced*
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Kidney Diseases / diagnosis
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Leucovorin / administration & dosage
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Male
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Methotrexate / administration & dosage
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Methotrexate / adverse effects*
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Obesity / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Radioisotope Renography
Substances
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Antimetabolites, Antineoplastic
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Leucovorin
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Methotrexate