Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects

Peter M Emmer; Eric A P Steegers; Marié Jose van Lierop; Régine P M Steegers-Theunissen; Yung Way Loke; Irma Joosten

doi:10.1016/s0378-3782(01)00236-5

Amniotic fluid soluble human leukocyte antigen G is markedly decreased in offspring with neural tube defects

Early Hum Dev. 2002 Feb;66(2):101-5. doi: 10.1016/s0378-3782(01)00236-5.

Authors

Peter M Emmer¹, Eric A P Steegers, Marié Jose van Lierop, Régine P M Steegers-Theunissen, Yung Way Loke, Irma Joosten

Affiliation

¹ Department of Bloodtransfusion and Transplantation Immunology, University Medical Center Nijmegen, Geert Grooteplein 10, PO Box 9101, 6500 HB, huispost 603/ABTI, Nijmegen, The Netherlands.

PMID: 11872314
DOI: 10.1016/s0378-3782(01)00236-5

Abstract

Pregnancies affected by a neural tube defect show changes in thymus morphology, neonatal and maternal T-cell repertoire. Amniotic fluid levels of soluble human leukocyte antigen G (HLA-G) (an immuno-modulatory protein) were found to be significantly lower as compared to controls. This may reflect a diminished cell-mediated immunity in neural tube defects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amniocentesis
Amniotic Fluid / chemistry
Amniotic Fluid / immunology*
Female
HLA Antigens / analysis
HLA Antigens / biosynthesis*
HLA-G Antigens
Histocompatibility Antigens Class I / analysis
Histocompatibility Antigens Class I / biosynthesis*
Humans
Neural Tube Defects / immunology*
Neural Tube Defects / metabolism
Pregnancy

Substances

HLA Antigens
HLA-G Antigens
Histocompatibility Antigens Class I