Akanthomycin, a new antibiotic pyridone from the entomopathogenic fungus Akanthomyces gracilis

Org Lett. 2002 Mar 7;4(5):671-3. doi: 10.1021/ol016737q.

Abstract

[structure: see text] Organic extracts of the entomopathogenic fungus Akanthomyces gracilis ARS 2910 contained antibiotics active against Staphylococcus aureus. Bioassay-guided fractionation of the CH2Cl2 extract yielded the antibacterial compound akanthomycin as a mixture of atropisomers along with the closely related compounds 8-methylpyridoxatin and cordypyridone C. Akanthomycin was characterized using X-ray crystallography and NMR.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Ants / microbiology
  • Crystallography, X-Ray
  • Fungi / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Pyridones / chemistry*
  • Pyridones / isolation & purification
  • Pyridones / pharmacology
  • Staphylococcus aureus / drug effects

Substances

  • 8-methylpyridoxatin
  • Anti-Bacterial Agents
  • Pyridones
  • akanthomycin
  • cordypyridone C