Abstract
A series of synthetic spongiane-type diterpenes have been tested in vitro for their potential antitumor and antiherpetic activity. Although the antiviral activity of these compounds against herpes simplex virus type 2 (HSV-2) was very weak, some compounds exhibited relevant cytotoxicity in the human tumor cell lines HeLa and HEp-2. The biological activity of formyl spongianes is reported for the first time. With the present study, some structure-activity trends are suggested for the cytotoxic activity of these sponge-derived natural products.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology
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Cricetinae
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Cricetulus
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Ear
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Fibroblasts
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HeLa Cells / drug effects
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Herpesvirus 2, Human / drug effects*
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Humans
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Inhibitory Concentration 50
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Laryngeal Neoplasms
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Molecular Structure
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Porifera / chemistry*
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Skin
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Stereoisomerism
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Structure-Activity Relationship
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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Antiviral Agents
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Diterpenes
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isoagatholactone