Objective: To investigate the therapeutic action of synthetic interleukin-1 blockers on uveitis in rats.
Method: Experiments were performed on 18 Spraque-Dawley rats (36 eyes), and the retinal interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) were quantified by an enzyme-linked immunoabsorbent assay (ELISA) before and after the rats with uveitis treated by synthetic interleukin-1 blockers.
Result: The retinal IL-1 beta and TNF-alpha in rats with uveitis treated by synthetic IL-1 blockers (CK-138, 139) were significantly decreased than those treated by contrasting design.
Conclusion: Synthetic IL-1 blockers (CK-138, 139) are effective in treatment of IL-1 alpha induced uveitis in the rat.