Abstract
The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-9) M). 5b also showed potency in the screen for colon cancer and leukemia.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antineoplastic Agents, Phytogenic / administration & dosage
-
Antineoplastic Agents, Phytogenic / chemical synthesis*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Bridged-Ring Compounds / chemistry
-
Drug Screening Assays, Antitumor
-
Humans
-
Indoles / chemistry
-
Leukemia, Experimental / drug therapy
-
Leukemia, Experimental / mortality
-
Mice
-
Nitrogen
-
Structure-Activity Relationship
-
Tumor Cells, Cultured
-
Vinblastine / chemistry
-
Vinca Alkaloids / administration & dosage
-
Vinca Alkaloids / chemical synthesis*
-
Vinca Alkaloids / pharmacology*
Substances
-
Antineoplastic Agents, Phytogenic
-
Bridged-Ring Compounds
-
Indoles
-
Vinca Alkaloids
-
Vinblastine
-
Nitrogen