Beta-blockers in left ventricular systolic dysfunction--from evidence to practice

Age Ageing. 2002 Jan;31(1):23-8. doi: 10.1093/ageing/31.1.23.

Abstract

Five percent of all hospital medical admissions are patients with heart failure. The incidence is about one new case per 1000 of the general population per year, increasing to >10 per 1000 in those aged >or=85 years. Although the evidence that beta-blockers reduce mortality by about 36% when added to angiotensin-converting enzyme inhibitors is overwhelming, clinicians are still reluctant to use beta-blockers in heart failure, especially in older patients. Here, we examine the evidence for the use of beta-blockers in heart failure in older people and explore the practicalities of their use.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use*
  • Aged
  • Aged, 80 and over
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
  • Coronary Disease / drug therapy*
  • Female
  • Humans
  • Male
  • Ventricular Dysfunction, Left / drug therapy*

Substances

  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors