Abstract
A new iridoid, pedunculariside, together with the known iridoid agnuside were isolated from the butanol extract of Vitex peduncularis stem bark. Both pedunculariside and agnuside showed preferential inhibition of COX-2, with IC50 values of 0.15 +/- 0.21 mg/ml and 0.026 +/- 0.015 mg/ml respectively, while having only small inhibitory effects on COX-1. Both compounds did not exhibit cytotoxicity against vero cells.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification
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Anti-Inflammatory Agents / pharmacology*
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Chlorocebus aethiops
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Cyclooxygenase 1
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Cyclooxygenase 2
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Iridoids
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / metabolism
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Magnetic Resonance Spectroscopy
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Membrane Proteins
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Mice
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Prostaglandin-Endoperoxide Synthases / metabolism
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Pyrans / chemistry
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Pyrans / isolation & purification
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Pyrans / pharmacology*
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Vero Cells / cytology
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Vero Cells / drug effects
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Vitex*
Substances
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Anti-Inflammatory Agents
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Glucosides
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Iridoids
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Isoenzymes
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Membrane Proteins
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Plant Extracts
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Pyrans
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pedunculariside
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Cyclooxygenase 1
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Cyclooxygenase 2
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Prostaglandin-Endoperoxide Synthases
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Ptgs1 protein, mouse
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agnuside