A new clue at the nuclear pore: RanBP2 is an E3 enzyme for SUMO1

Yoshiaki Azuma; Mary Dasso

doi:10.1016/s1534-5807(02)00124-7

A new clue at the nuclear pore: RanBP2 is an E3 enzyme for SUMO1

Dev Cell. 2002 Feb;2(2):130-1. doi: 10.1016/s1534-5807(02)00124-7.

Authors

Yoshiaki Azuma¹, Mary Dasso

Affiliation

¹ Laboratory of Gene Regulation and Development, NICHD/NIH, Building 18, Room 106, Bethesda, MD 20892, USA.

PMID: 11832237
DOI: 10.1016/s1534-5807(02)00124-7

Abstract

A recent paper in Cell shows that the large nucleoporin RanBP2 can act as an E3 enzyme for the ubiquitin-like protein SUMO1. These intriguing results raise important questions about the mechanism of SUMO1 conjugation, the relationship of SUMO1 to nuclear transport, and the regulation of RanBP2 in the pore.

MeSH terms

Active Transport, Cell Nucleus
Molecular Chaperones
Nuclear Pore / enzymology
Nuclear Pore / metabolism*
Nuclear Pore Complex Proteins / metabolism*
SUMO-1 Protein / metabolism*

Substances

Molecular Chaperones
Nuclear Pore Complex Proteins
SUMO-1 Protein
ran-binding protein 2