Objective: To study whether there is chromaffin cells hyperplasia in adrenocortical hyperplasia and adenoma.
Methods: Chromaffin cells with chromogranin A were marked by immunohistochemistry method.
Results: In 52 cases of adrenocortical hyperplasia and adenoma 3 were associated with eochromocyte hyperplasia and 5 with micro-pheochromocytoma. Six of the 8 cases were characterized by hypercortiso (or aldostero)-hypercatecholamine clinically.
Conclusions: Few cases of adrenocortical hyperplasia and adenoma may be associated with pheochromocytic hyperplasia and micro-pheochromocytoma, and may be characterized by symptoms of hypercortiso (or aldostero)-hypercatecholamine.