Structure-activity relationships for analogues of the phenazine-based dual topoisomerase I/II inhibitor XR11576

Bioorg Med Chem Lett. 2002 Feb 11;12(3):415-8. doi: 10.1016/s0960-894x(01)00770-3.

Abstract

As part of a programme to identify further analogues of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various 'minimal' and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576.

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Indicators and Reagents
  • Phenazines / chemistry*
  • Phenazines / pharmacology*
  • Structure-Activity Relationship
  • Topoisomerase I Inhibitors*
  • Topoisomerase II Inhibitors*
  • Tumor Cells, Cultured

Substances

  • 4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide
  • Antineoplastic Agents
  • Indicators and Reagents
  • Phenazines
  • Topoisomerase I Inhibitors
  • Topoisomerase II Inhibitors