Abstract
As part of a programme to identify further analogues of the dual topo I/II inhibitor XR11576, we describe here the syntheses and SAR studies of various 'minimal' and 3,4-benzofused phenazine chromophores of the phenazine template of XR11576.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Drug Screening Assays, Antitumor
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Humans
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Indicators and Reagents
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Phenazines / chemistry*
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Phenazines / pharmacology*
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Structure-Activity Relationship
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Topoisomerase I Inhibitors*
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Topoisomerase II Inhibitors*
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Tumor Cells, Cultured
Substances
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4-methoxybenzo(a)phenazine-11-carboxylic acid (2-(dimethylamino)-1-methylethyl)amide
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Antineoplastic Agents
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Indicators and Reagents
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Phenazines
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Topoisomerase I Inhibitors
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Topoisomerase II Inhibitors