Abstract
Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus.
Cases:
We report two infants with metopic craniosynostosis, born to mothers who were treated with valproic acid. In one case, a prenatal diagnosis was made. In the other case, only the male dizygotic twin was affected.
Conclusion:
Trigonocephaly may be a symptom of valproate embryofoetopathy detectable by antenatal ultrasound examination.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Abnormalities, Drug-Induced / diagnosis
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Abnormalities, Drug-Induced / etiology*
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Craniosynostoses / chemically induced*
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Craniosynostoses / diagnosis
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Diseases in Twins
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Epilepsy, Generalized / drug therapy*
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Female
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Humans
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Imaging, Three-Dimensional
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Infant, Newborn
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Male
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Pregnancy
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Pregnancy Complications / drug therapy*
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Tomography, X-Ray Computed
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Twins, Dizygotic
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Ultrasonography, Prenatal
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Valproic Acid / adverse effects*
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Valproic Acid / therapeutic use