New lanostanoids from the mushroom Ganoderma lucidum

J Nat Prod. 2002 Jan;65(1):72-5. doi: 10.1021/np010385e.

Abstract

From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-hydroxylganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated. The structures of 1-3 were determined by interpretation of their spectroscopic data.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Inhibitory Concentration 50
  • Interferon-gamma / analysis
  • Interferon-gamma / blood
  • Interleukin-2 / analysis
  • Interleukin-2 / blood
  • Interleukin-4 / analysis
  • Interleukin-4 / blood
  • Lanosterol / analogs & derivatives
  • Lanosterol / chemistry
  • Lanosterol / isolation & purification*
  • Lanosterol / pharmacology
  • Leukocytes, Mononuclear / drug effects
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Reishi / chemistry*
  • Reishi / immunology
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet

Substances

  • 20-hydroxylganoderic acid G
  • 8,9-dihydroganoderate J
  • 8,9-dihydroganoderic acid J
  • Drugs, Chinese Herbal
  • Interleukin-2
  • Lanosterol
  • Interleukin-4
  • Interferon-gamma