Abstract
From a lipophilic extract of the fruiting body of Ganoderma lucidum, three new lanostanoids, 8beta,9alpha-dihydroganoderic acid J (1), methyl 8beta,9alpha-dihydroganoderate J (2), and 20-hydroxylganoderic acid G (3), along with 12 known lanostanoids and two ergostane sterols were isolated. The structures of 1-3 were determined by interpretation of their spectroscopic data.
MeSH terms
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Chromatography, High Pressure Liquid
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Enzyme-Linked Immunosorbent Assay
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Humans
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Inhibitory Concentration 50
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Interferon-gamma / analysis
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Interferon-gamma / blood
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Interleukin-2 / analysis
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Interleukin-2 / blood
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Interleukin-4 / analysis
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Interleukin-4 / blood
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Lanosterol / analogs & derivatives
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Lanosterol / chemistry
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Lanosterol / isolation & purification*
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Lanosterol / pharmacology
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Leukocytes, Mononuclear / drug effects
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Reishi / chemistry*
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Reishi / immunology
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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20-hydroxylganoderic acid G
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8,9-dihydroganoderate J
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8,9-dihydroganoderic acid J
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Drugs, Chinese Herbal
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Interleukin-2
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Lanosterol
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Interleukin-4
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Interferon-gamma