Abstract
Bioactivity-guided fractionation of a methanol extract from the leaves of Piper lanceaefolium resulted in the isolation of four new benzoic acid derivatives (1-4), together with taboganic acid, pinocembrin, and pinocembrin chalcone. Lanceaefolic acid methyl ester (3) and pinocembrin chalcone displayed activity against Candida albicans with a minimal inhibitory concentration value of 100 microg/mL in both cases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification*
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Antifungal Agents / pharmacology
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Benzoates / chemistry
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Benzoates / isolation & purification*
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Benzoates / pharmacology
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Candida albicans / drug effects
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Chromatography, Thin Layer
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Colombia
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Flavanones*
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Piperaceae / chemistry*
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Toxicity Tests
Substances
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Antifungal Agents
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Benzoates
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Flavanones
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Flavonoids
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pinocembrin