Antifungal activity of benzoic acid derivatives from Piper lanceaefolium

J Nat Prod. 2002 Jan;65(1):62-4. doi: 10.1021/np010410g.

Abstract

Bioactivity-guided fractionation of a methanol extract from the leaves of Piper lanceaefolium resulted in the isolation of four new benzoic acid derivatives (1-4), together with taboganic acid, pinocembrin, and pinocembrin chalcone. Lanceaefolic acid methyl ester (3) and pinocembrin chalcone displayed activity against Candida albicans with a minimal inhibitory concentration value of 100 microg/mL in both cases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology
  • Benzoates / chemistry
  • Benzoates / isolation & purification*
  • Benzoates / pharmacology
  • Candida albicans / drug effects
  • Chromatography, Thin Layer
  • Colombia
  • Flavanones*
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification
  • Flavonoids / pharmacology
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Piperaceae / chemistry*
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Toxicity Tests

Substances

  • Antifungal Agents
  • Benzoates
  • Flavanones
  • Flavonoids
  • pinocembrin