Antiviral Chinese medicinal herbs against respiratory syncytial virus

J Ethnopharmacol. 2002 Feb;79(2):205-11. doi: 10.1016/s0378-8741(01)00389-0.

Abstract

Forty-four medicinal herbs were tested for antiviral activities against respiratory syncytial virus (RSV) by means of the cytopathologic effect (CPE) assay. Twenty-seven of the 44 medicinal herbs showed potent or moderate antiviral activities against RSV with 50% inhibition concentration (IC(50)) ranging from 6.3 to 52.1 microg/ml, and with selectivity index (SI) ranging from 2.0 to 32.1. Further purification of the active extracts from Sophora flavescens Ait. and Scutellaria baicalensis Georgi led to the identification of anagyrine (2), oxymatrine (7), sophoranol (10), wogonin (12), and oroxylin A (13) as the potent anti-RSV components.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Cytopathogenic Effect, Viral / drug effects
  • Cytopathogenic Effect, Viral / physiology
  • Drug Evaluation, Preclinical / methods
  • Drug Evaluation, Preclinical / statistics & numerical data
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology*
  • Drugs, Chinese Herbal / therapeutic use
  • Flavanones*
  • Flavonoids / chemistry
  • Flavonoids / pharmacology
  • Flavonoids / therapeutic use
  • Phytotherapy / methods
  • Phytotherapy / statistics & numerical data
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Roots / chemistry
  • Respiratory Syncytial Viruses / drug effects*
  • Respiratory Syncytial Viruses / growth & development
  • Sophora / chemistry
  • Tumor Cells, Cultured

Substances

  • Antiviral Agents
  • Drugs, Chinese Herbal
  • Flavanones
  • Flavonoids
  • Plant Extracts
  • scutellarein