[Changes of serum elastase, alpha 1-antitrypsin, procollagen III peptide and malonaldehyde in smokers with and without chronic obstructive pulmonary diseases]

Zhonghua Nei Ke Za Zhi. 1999 Mar;38(3):178-80.
[Article in Chinese]

Abstract

Objective: Serum elastase, alpha(1)-antitrypsin (alpha(1)-AT), procollagen III peptide (PIIIP) and malonaldehyde (MDA) were studied in smokers with and without chronic obstructive pulmonary disease (COPD) to explore the roles of these factors in COPD induced by smoking.

Methods: A design of 154-pair case-control study was used. alpha(1)-AT, MDA and PIIIP were determined with colorimetric method, fluo-spectrophotometric method and radio-immunological assay, respectively, in non-smoker control and smokers with and without COPD.

Results: Serum PIIIP content was increased in smokers and alpha(1)-AT decreased significantly in patients with COPD.

Conclusion: Decreased alpha(1)-AT may be a susceptible factor in the development of COPD caused by smoking.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Humans
  • Male
  • Malondialdehyde / blood
  • Middle Aged
  • Pancreatic Elastase / blood
  • Peptide Fragments / blood*
  • Procollagen / blood*
  • Pulmonary Disease, Chronic Obstructive / blood*
  • Pulmonary Disease, Chronic Obstructive / etiology
  • Smoking / adverse effects
  • Smoking / blood*
  • alpha 1-Antitrypsin / analysis*

Substances

  • Peptide Fragments
  • Procollagen
  • alpha 1-Antitrypsin
  • procollagen Type III-N-terminal peptide
  • Malondialdehyde
  • Pancreatic Elastase