Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides

H B Lazrek; M Taourirte; T Oulih; J L Barascut; J L Imbach; C Pannecouque; M Witrouw; E De Clercq

doi:10.1081/NCN-100108325

Synthesis and anti-HIV activity of new modified 1,2,3-triazole acyclonucleosides

Nucleosides Nucleotides Nucleic Acids. 2001 Dec;20(12):1949-60. doi: 10.1081/NCN-100108325.

Authors

H B Lazrek¹, M Taourirte, T Oulih, J L Barascut, J L Imbach, C Pannecouque, M Witrouw, E De Clercq

Affiliation

¹ Laboratoire de Chimie Bio-Organique, Faculté des Sciences Semlalia, Marrakech, Maroc.

PMID: 11794800
DOI: 10.1081/NCN-100108325

Abstract

The synthesis of 1,2,3-triazole acyclonucleosides 7a-h via 1,3-dipolar cycloaddition of N-9/N-1-propargylpurine/pyrimidine 2a-h with azido-pseudo-sugar 4 is described and none of them had anti-HIV activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / pharmacology*
Biochemistry / methods
HIV-1 / drug effects
HIV-2 / drug effects
Microbial Sensitivity Tests
Nucleosides / chemical synthesis
Nucleosides / chemistry*
Nucleosides / pharmacology*
Structure-Activity Relationship
Triazoles / chemistry*

Substances

Anti-HIV Agents
Nucleosides
Triazoles