Abstract
Objective:
To investigate the molecular biological mechanism of anti-epileptic effect of Tsaoko-Anemarrhenae decoction (TAD) on epileptic model rats.
Methods:
The pentylenetetrazol (PTZ) induced epileptic Sprague-Dawley rats were selected as the animal model. The effects of TAD on the c-fos, c-jun gene expression in the rats' brain were observed by in situ hybridisation.
Results:
The c-fos, c-jun gene expression was obviously increased, TAD could effectively block the gene expression of c-fos, c-jun, showing better antiepileptic effect.
Conclusion:
The mechanism of TAD anti-epileptic effect might be correlated to the decrease of c-fos, c-jun gene expression.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anticonvulsants / pharmacology*
-
Brain / metabolism
-
Drugs, Chinese Herbal / pharmacology*
-
Epilepsy / chemically induced
-
Epilepsy / metabolism*
-
Epilepsy / physiopathology
-
Kindling, Neurologic
-
Male
-
Pentylenetetrazole
-
Proto-Oncogene Proteins c-fos / biosynthesis*
-
Proto-Oncogene Proteins c-fos / genetics
-
Proto-Oncogene Proteins c-jun / biosynthesis*
-
Proto-Oncogene Proteins c-jun / genetics
-
RNA, Messenger / biosynthesis
-
RNA, Messenger / genetics
-
Random Allocation
-
Rats
-
Rats, Sprague-Dawley
Substances
-
Anticonvulsants
-
Drugs, Chinese Herbal
-
Proto-Oncogene Proteins c-fos
-
Proto-Oncogene Proteins c-jun
-
RNA, Messenger
-
Pentylenetetrazole