Fat-soluble vitamin status is not affected by diacylglycerol consumption

Ann Nutr Metab. 2001;45(6):259-64. doi: 10.1159/000046736.

Abstract

Objective: The objective of this study was to examine the effect of dietary diacylglycerol (DAG) on the bioavailability of fat-soluble vitamins in comparison with triacylglycerol (TAG).

Methods: We conducted a long-term administration test of DAG and TAG in 27 healthy men aged 27-47 years. After measuring baseline values, subjects were randomized into two groups, one group (n = 15) was given DAG and the other (n = 12) was given TAG. Subjects ingested 20 g of DAG or TAG either in mayonnaise or an emulsion drink of their own choice at meals once a day for 12 weeks. At 4, 8 and 12 weeks, fasting blood samples were drawn and serum levels of vitamin A, E, and D were measured.

Results: There were no significant changes in vitamin A levels throughout the study period. Compared to the initial values (using a Student's t test for paired values), significant differences of vitamin E and D were seen at some points during the experiment. According to a two-way repeated measures analysis of variance, however, DAG and TAG (lipid) and time had no effect on fat-soluble vitamin levels.

Conclusions: Our results indicate that DAG does not affect the absorption of the fat-soluble vitamins in diets.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analysis of Variance
  • Biological Availability
  • Diglycerides / administration & dosage*
  • Double-Blind Method
  • Humans
  • Intestinal Absorption
  • Male
  • Middle Aged
  • Nutritional Status
  • Triglycerides / administration & dosage*
  • Vitamin A / blood
  • Vitamin A / pharmacokinetics*
  • Vitamin D / blood
  • Vitamin D / pharmacokinetics*
  • Vitamin E / blood
  • Vitamin E / pharmacokinetics*

Substances

  • Diglycerides
  • Triglycerides
  • Vitamin A
  • Vitamin D
  • Vitamin E