AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy

Bioelectrochemistry. 2002 Jan;55(1-2):17-9. doi: 10.1016/s1567-5394(01)00171-2.

Abstract

Large unilamellar magnetoliposomes (MLs) with encapsulated doxorubicin (DOX) (anticancer drug) were prepared by reverse-phase evaporation. They were exposed to an alternating magnetic field with a frequency of 3.5 MHz and an induction of 1.5 mT produced in three-turn pancake coil. The results showed that magnetoliposomes could be specifically heated to 42 degrees C (phase transition temperature of a used lipid) in a few minutes and during this, the encapsulated doxorubicin is massively released.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / pharmacokinetics
  • Doxorubicin / administration & dosage*
  • Doxorubicin / pharmacokinetics
  • Liposomes*
  • Magnetics*

Substances

  • Antibiotics, Antineoplastic
  • Liposomes
  • Doxorubicin