The evolution of the MHC-G gene does not support a functional role for the complete protein

Immunol Rev. 2001 Oct:183:65-75. doi: 10.1034/j.1600-065x.2001.1830105.x.

Abstract

The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-G-like proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cebidae / genetics
  • Cercopithecidae / genetics
  • Evolution, Molecular
  • Genes, MHC Class I*
  • HLA Antigens / chemistry
  • HLA Antigens / physiology*
  • HLA-G Antigens
  • Histocompatibility Antigens Class I / chemistry
  • Histocompatibility Antigens Class I / physiology*
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Polymorphism, Genetic

Substances

  • HLA Antigens
  • HLA-G Antigens
  • Histocompatibility Antigens Class I