Abstract
The study of the MHC-G gene evolution during nearly 40 million years does not support a role for the full molecule. The MHC-G-like proteins of New World monkeys are probably classical presenting molecules. Old World Cercopithecinae monkeys do not have a full MHC-G molecule and human individuals homozygous for the HLA-G null allele are healthy and do not show birth pathologies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cebidae / genetics
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Cercopithecidae / genetics
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Evolution, Molecular
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Genes, MHC Class I*
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HLA Antigens / chemistry
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HLA Antigens / physiology*
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HLA-G Antigens
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Histocompatibility Antigens Class I / chemistry
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Histocompatibility Antigens Class I / physiology*
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Humans
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Models, Molecular
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Molecular Sequence Data
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Polymorphism, Genetic
Substances
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I