Low-density lipoprotein-antioxidant constituents of Saururus chinensis

J Nat Prod. 2001 Dec;64(12):1562-4. doi: 10.1021/np0006061.

Abstract

A new diarylbutane lignan, saururin A (1), and a known 8-O-4'-type neolignan, machilin D (2), were isolated from a total methanol extract of the underground parts of Saururus chinensis. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1, 2, and virolin (3) (the methyl ether of 2) exhibited significant low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substance (TBARS) assay with IC(50) values of 8.5, 2.9, and 4.3 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology
  • Chromatography, Thin Layer
  • Humans
  • Inhibitory Concentration 50
  • Korea
  • Lignans / chemistry
  • Lignans / isolation & purification*
  • Lignans / pharmacology
  • Lipoproteins, LDL / blood*
  • Magnoliopsida / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Spectrophotometry, Infrared
  • Stereoisomerism
  • Thiobarbituric Acid Reactive Substances / analysis

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antioxidants
  • Lignans
  • Lipoproteins, LDL
  • Thiobarbituric Acid Reactive Substances
  • machilin D
  • saururin A
  • virolin