Abstract
A new diarylbutane lignan, saururin A (1), and a known 8-O-4'-type neolignan, machilin D (2), were isolated from a total methanol extract of the underground parts of Saururus chinensis. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1, 2, and virolin (3) (the methyl ether of 2) exhibited significant low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substance (TBARS) assay with IC(50) values of 8.5, 2.9, and 4.3 microM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antioxidants / chemistry
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Antioxidants / isolation & purification*
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Antioxidants / pharmacology
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Chromatography, Thin Layer
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Humans
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Inhibitory Concentration 50
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Korea
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Lipoproteins, LDL / blood*
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Magnoliopsida / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Spectrophotometry, Infrared
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Stereoisomerism
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Thiobarbituric Acid Reactive Substances / analysis
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Lignans
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Lipoproteins, LDL
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Thiobarbituric Acid Reactive Substances
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machilin D
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saururin A
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virolin