A mercapto analogue of 5'-noraristeromycin

Bioorg Med Chem. 2002 Feb;10(2):457-60. doi: 10.1016/s0968-0896(01)00271-1.

Abstract

5'-Noraristeromycin and its enantiomer have been found to possess a wide range of antiviral effects. In the search for analogues of and with improved activity, the synthesis of both enantiomers of 5'-mercapto-5'-deoxy-5'-noraristeromycin ( and ) has been accomplished. While (+)-7 was inactive, (-)- did show marginal activity against vaccinia virus, but not any other virus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemistry*
  • Adenosine / pharmacology
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology*
  • Biochemistry / methods
  • Drug Evaluation, Preclinical / methods
  • Structure-Activity Relationship
  • Vaccinia virus / drug effects

Substances

  • Antiviral Agents
  • 5'-noraristeromycin
  • Adenosine