Abstract
5'-Noraristeromycin and its enantiomer have been found to possess a wide range of antiviral effects. In the search for analogues of and with improved activity, the synthesis of both enantiomers of 5'-mercapto-5'-deoxy-5'-noraristeromycin ( and ) has been accomplished. While (+)-7 was inactive, (-)- did show marginal activity against vaccinia virus, but not any other virus.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemistry*
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Adenosine / pharmacology
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology*
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Biochemistry / methods
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Drug Evaluation, Preclinical / methods
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Structure-Activity Relationship
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Vaccinia virus / drug effects
Substances
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Antiviral Agents
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5'-noraristeromycin
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Adenosine