Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke

Neurology. 2001 Dec 11;57(11):2120-2. doi: 10.1212/wnl.57.11.2120.

Abstract

Changes in brain tissue volume in six patients who had acute complete middle cerebral artery (MCA) infarctions and CT evidence of midline shift were measured using the brain boundary shift integral (BBSI) on sequential T1-weighted MR images acquired before and after a 1.5-g/kg bolus infusion of mannitol. At 50 to 55 minutes after the baseline scan, total brain volume decreased by 8.1 +/- 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 +/- 0.4%) than in the infarcted hemisphere (0.0 +/- 0.5%, p < 0.05).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Atrophy
  • Brain / drug effects
  • Brain / pathology
  • Brain Edema / diagnosis
  • Brain Edema / drug therapy*
  • Brain Mapping
  • Disease Progression
  • Dominance, Cerebral / drug effects
  • Dominance, Cerebral / physiology
  • Female
  • Humans
  • Infarction, Middle Cerebral Artery / diagnosis
  • Infarction, Middle Cerebral Artery / drug therapy*
  • Infusions, Intravenous
  • Magnetic Resonance Imaging*
  • Male
  • Mannitol / administration & dosage
  • Mannitol / adverse effects*
  • Middle Aged
  • Tomography, X-Ray Computed*

Substances

  • Mannitol