In vitro susceptibility of clinical isolates of Zygomycota to amphotericin B, flucytosine, itraconazole and voriconazole

J Antimicrob Chemother. 2001 Dec;48(6):919-21. doi: 10.1093/jac/48.6.919.

Abstract

The in vitro susceptibility of 29 clinical isolates of fungi belonging to the division Zygomycota was reviewed. A broth microdilution test was performed by following the NCCLS reference method, with minor modifications. The species of Zygomycota tested were resistant in vitro to flucytosine, itraconazole and voriconazole. Amphotericin B showed the best activity against most of the strains evaluated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Flucytosine / pharmacology
  • Fungi / drug effects*
  • Fungi / growth & development
  • Fungi / isolation & purification*
  • Humans
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests / methods
  • Pyrimidines / pharmacology
  • Triazoles / pharmacology
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Amphotericin B
  • Flucytosine
  • Voriconazole