Analgesic sesquiterpene dilactone from Mikania cordata

Fitoterapia. 2001 Dec;72(8):919-21. doi: 10.1016/s0367-326x(01)00318-5.

Abstract

The crude extract of Mikania cordata (1 and 3 g/kg, p.o.) and deoxymikanolide (1) (10 mg/kg, p.o.) significantly inhibited acetic acid-induced writhing in mice. Three other sesquiterpene dilactones isolated from the same plant, namely mikanolide, dihydromikanolide and scandenolide, did not show significant analgesic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetic Acid
  • Analgesics / administration & dosage
  • Analgesics / pharmacology*
  • Analgesics / therapeutic use
  • Animals
  • Asteraceae*
  • Dose-Response Relationship, Drug
  • Lactones / administration & dosage
  • Lactones / pharmacology*
  • Lactones / therapeutic use
  • Male
  • Mice
  • Pain / chemically induced
  • Pain / prevention & control*
  • Pain Measurement / drug effects*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Sesquiterpenes / administration & dosage
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes / therapeutic use
  • Sesquiterpenes, Germacrane*

Substances

  • Analgesics
  • Lactones
  • Plant Extracts
  • Sesquiterpenes
  • Sesquiterpenes, Germacrane
  • deoxymikanolide
  • Acetic Acid