The increased polarity of evidenced-based medicine has changed the approach to evaluation of medical interventions and treatments, either placing them on firm scientific foundations or suggesting that evidence is inadequate to strongly support current or innovative practices. Airway management devices and techniques are essential and common components of clinical care. It is the purpose of this review to identify the levels of evidence that support common and novel techniques in airway management. Very few airway management techniques are supported by large, prospective randomized trials. In resuscitation, defibrillation should take priority over airway management. This is supported by animal studies and several reported series of patient experiences and will never be subjected to a prospective randomized trial. Substantial evidence supports the use of noninvasive ventilation, subglottic endotracheal tube secretion removal, changing ventilator circuits no more frequently than every 7 days, and the use of selective digestive decontamination with systemic antibiotics to reduce the incidence of ventilator-associated pneumonia. Little evidence supports using other measures such as elevating the head of the bed to 30% (but this costs nothing and is intrinsically attractive), use of heat and moisture exchangers, kinetic bed therapy, early tracheotomy, or lung secretion removal techniques to reduce ventilator-associated pneumonia. Percutaneous tracheotomy currently can only be recommended over open surgical tracheotomy based on cost, convenience and late stomal complications; it may be associated with a slightly higher morbidity and mortality.