A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus

J Nat Prod. 2001 Nov;64(11):1457-9. doi: 10.1021/np0101806.

Abstract

A new dimeric stilbene, namely, artogomezianol (1), and the known compound andalasin A (2) were isolated from the roots of Artocarpus gomezianus. Both 1 and 2 showed moderate tyrosinase inhibitory activity with IC(50) values of 68 and 39 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromatography
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Inhibitory Concentration 50
  • Molecular Conformation
  • Molecular Structure
  • Monophenol Monooxygenase / antagonists & inhibitors*
  • Moraceae / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Stilbenes / chemistry
  • Stilbenes / isolation & purification*
  • Stilbenes / pharmacology
  • Structure-Activity Relationship
  • Thailand

Substances

  • Enzyme Inhibitors
  • Stilbenes
  • andalasin A
  • artogomezianol
  • Monophenol Monooxygenase