Receptor-Ck regulates giardia encystation process

Mol Cell Biochem. 2001 Sep;225(1-):167-9. doi: 10.1023/a:1012277001794.

Abstract

The study addressed to resolve the mechanism involved in cholesterol-dependent regulation of giardia encystation process, revealed that (a) the trophozoites have the ability to express genes coding for receptor-Ck and sterol element binding protein (SREBP); (b) inhibition of cholesterol dependent activation of receptor-Ck results in the upregulation of CWP-1 gene expression leading to encystation process. Based upon these findings, we propose that receptor-Ck dependent signalling is responsible for the regulation of giardia encystation process by cholesterol.

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins / metabolism
  • Cells, Cultured
  • Cholesterol / metabolism
  • DNA-Binding Proteins / metabolism
  • Giardia / growth & development*
  • Giardia / metabolism*
  • Protozoan Proteins / metabolism
  • Receptors, Lipoprotein / antagonists & inhibitors
  • Receptors, Lipoprotein / metabolism*
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors*

Substances

  • CCAAT-Enhancer-Binding Proteins
  • CWP1 protein, Giardia lamblia
  • DNA-Binding Proteins
  • Protozoan Proteins
  • Receptors, Lipoprotein
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • receptor-Ck
  • Cholesterol