Abstract
The study addressed to resolve the mechanism involved in cholesterol-dependent regulation of giardia encystation process, revealed that (a) the trophozoites have the ability to express genes coding for receptor-Ck and sterol element binding protein (SREBP); (b) inhibition of cholesterol dependent activation of receptor-Ck results in the upregulation of CWP-1 gene expression leading to encystation process. Based upon these findings, we propose that receptor-Ck dependent signalling is responsible for the regulation of giardia encystation process by cholesterol.
MeSH terms
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Animals
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CCAAT-Enhancer-Binding Proteins / metabolism
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Cells, Cultured
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Cholesterol / metabolism
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DNA-Binding Proteins / metabolism
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Giardia / growth & development*
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Giardia / metabolism*
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Protozoan Proteins / metabolism
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Receptors, Lipoprotein / antagonists & inhibitors
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Receptors, Lipoprotein / metabolism*
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors*
Substances
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CCAAT-Enhancer-Binding Proteins
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CWP1 protein, Giardia lamblia
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DNA-Binding Proteins
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Protozoan Proteins
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Receptors, Lipoprotein
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors
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receptor-Ck
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Cholesterol