Modification of membrane-toxic effect of Nd-YAG laser by preliminary induction of cytochrome P-450 in bone marrow cells

E Y Stavitskaya; A B Egorova; V V Salmin; S N Zobova; A S Provorov

doi:10.1023/a:1013062802883

Modification of membrane-toxic effect of Nd-YAG laser by preliminary induction of cytochrome P-450 in bone marrow cells

Bull Exp Biol Med. 2001 Aug;132(2):811-3. doi: 10.1023/a:1013062802883.

Authors

E Y Stavitskaya¹, A B Egorova, V V Salmin, S N Zobova, A S Provorov

Affiliation

¹ Department of Pathophysiology with a Course of Functional Diagnosis, Krasnoyarsk State Medical Academy. onmpi@krsk.infotel.ru

PMID: 11713574
DOI: 10.1023/a:1013062802883

Abstract

The cytotoxic effects of Nd-YAG laser with a wavelength of 533 nm were studied in mouse bone marrow cells in vitro. Laser exposure caused blebbing of bone marrow cell plasma membrane. Preliminary induction of cytochrome P-450 with 3-methylcholanthrene modified the cytotoxic effect of Nd-YAG laser.

MeSH terms

Animals
Bone Marrow Cells / enzymology
Bone Marrow Cells / radiation effects*
Bone Marrow Cells / ultrastructure
Cell Membrane / radiation effects
Cell Membrane / ultrastructure
Cells, Cultured
Cytochrome P-450 Enzyme System / biosynthesis*
Drug Administration Schedule
Enzyme Induction
Injections, Intraperitoneal
Lasers / adverse effects*
Male
Malondialdehyde / analysis
Methylcholanthrene / administration & dosage
Methylcholanthrene / pharmacology*
Mice
Mice, Inbred Strains
Radiation-Protective Agents / administration & dosage
Radiation-Protective Agents / pharmacology*
Thiobarbituric Acid Reactive Substances / metabolism

Substances

Radiation-Protective Agents
Thiobarbituric Acid Reactive Substances
Malondialdehyde
Methylcholanthrene
Cytochrome P-450 Enzyme System