[1,3;1,6-beta-D-glucan translam: results of studying and prospects for application]

L A Ivanushko; N N Besednova; T S Zaporozhets; T N Zviagintseva

[1,3;1,6-beta-D-glucan translam: results of studying and prospects for application]

Antibiot Khimioter. 2001;46(7):14-8.

[Article in Russian]

Authors

L A Ivanushko¹, N N Besednova, T S Zaporozhets, T N Zviagintseva

Affiliation

¹ Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok.

PMID: 11697238

Abstract

The results of translam chemical structure and biological activity investigation are presented. Translam is a new original semisynthetic polysaccharide of marine origin. The preparation demonstrated potent treatment effect in experimental radiation disease. It had preventing effect at experimental bacterial infections, stimulated hematopoiesis, had effect on humoral and cell immunity and on factors of nonspecific organism resistance.

Publication types

English Abstract

MeSH terms

Acute Disease
Adjuvants, Immunologic / pharmacology*
Animals
Antibody-Producing Cells / drug effects
Cells, Cultured
Dogs
Escherichia coli Infections / mortality
Escherichia coli Infections / prevention & control
Glucans / pharmacology*
Guinea Pigs
Hematopoiesis / drug effects
Hypersensitivity, Delayed / prevention & control
Macrophages / drug effects
Macrophages / immunology
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Phagocytosis
Radiation Injuries, Experimental / blood
Radiation Injuries, Experimental / immunology
Radiation Injuries, Experimental / prevention & control
Yersinia pseudotuberculosis Infections / mortality
Yersinia pseudotuberculosis Infections / prevention & control

Substances

Adjuvants, Immunologic
Glucans
epiglucan