Abstract
2-(3,5,6-Trifluoro-2-hydroxy-4-methoxyphenyl)benzoxazole (3) and benzothiazole analogue (4) are prepared by the two-step procedures from the corresponding 2-(pentafluorophenyl)benzazoles. Benzoxazole 3 is applicable to a fluorescent probe sensing magnesium cation, and 4 is suitable for sensing zinc cation. Both fluorophores 3 and 4 are sensitive to the pH change at pH 7-8, resulting in large fluorescence enhancement under basic conditions. Their high sensitivity to pH and selectivity in metal cations are ascribed to the high acidity of the fluorophenol moiety.
MeSH terms
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Benzothiazoles
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Benzoxazoles / chemical synthesis*
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Benzoxazoles / chemistry*
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Biosensing Techniques
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Cations / analysis
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Hydrogen-Ion Concentration
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Metals / analysis*
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Molecular Probes / chemical synthesis
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Molecular Probes / chemistry
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Spectrum Analysis
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry*
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Zinc / analysis
Substances
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2-(3,5,6-trifluoro-2-hydroxy-4-methoxyphenyl)benzothiazole
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2-(3,5,6-trifluoro-2-hydroxy-4-methoxyphenyl)benzoxazole
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Benzothiazoles
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Benzoxazoles
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Cations
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Fluorescent Dyes
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Metals
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Molecular Probes
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Thiazoles
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benzothiazole
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Zinc