Allopurinol has immunomodulating activity following topical and systemic application in experimental autoimmune uveitis

Eur J Ophthalmol. 2001 Jul-Sep;11(3):252-60. doi: 10.1177/112067210101100307.

Abstract

Purpose: Allopurinol has beneficial effects in the systemic treatment of lens-induced uveitis and experimental autoimmune uveitis (EAU). This is believed to be due to a reduction of oxidative tissue damage through its dose-dependent free radical scavenging ability, and to an immunomodulating effect. The purpose of this study was to demonstrate the immunological effects on the IgG-antibody repertoire in EAU after topical and systemic allopurinol and steroids.

Methods: We assigned 43 male Lewis rats to 6 different groups: healthy rats (BASE, n=3)

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / therapeutic use*
  • Administration, Topical
  • Allopurinol / administration & dosage
  • Allopurinol / therapeutic use*
  • Animals
  • Autoantibodies / blood
  • Autoantigens / immunology
  • Autoimmune Diseases / chemically induced
  • Autoimmune Diseases / drug therapy*
  • Autoimmune Diseases / immunology
  • Blotting, Western
  • Disease Models, Animal
  • Electrophoresis, Polyacrylamide Gel
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / therapeutic use*
  • Glucocorticoids / administration & dosage
  • Glucocorticoids / therapeutic use
  • Immunoglobulin G / blood
  • Injections, Intravenous
  • Male
  • Rats
  • Rats, Inbred Lew
  • Uveitis / chemically induced
  • Uveitis / drug therapy*
  • Uveitis / immunology

Substances

  • Adjuvants, Immunologic
  • Autoantibodies
  • Autoantigens
  • Free Radical Scavengers
  • Glucocorticoids
  • Immunoglobulin G
  • Allopurinol