Abstract
Purpose:
Allopurinol has beneficial effects in the systemic treatment of lens-induced uveitis and experimental autoimmune uveitis (EAU). This is believed to be due to a reduction of oxidative tissue damage through its dose-dependent free radical scavenging ability, and to an immunomodulating effect. The purpose of this study was to demonstrate the immunological effects on the IgG-antibody repertoire in EAU after topical and systemic allopurinol and steroids.
Methods:
We assigned 43 male Lewis rats to 6 different groups: healthy rats (BASE, n=3)
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Adjuvants, Immunologic / therapeutic use*
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Administration, Topical
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Allopurinol / administration & dosage
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Allopurinol / therapeutic use*
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Animals
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Autoantibodies / blood
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Autoantigens / immunology
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Autoimmune Diseases / chemically induced
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Autoimmune Diseases / drug therapy*
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Autoimmune Diseases / immunology
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Blotting, Western
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Disease Models, Animal
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Electrophoresis, Polyacrylamide Gel
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / therapeutic use*
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Glucocorticoids / administration & dosage
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Glucocorticoids / therapeutic use
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Immunoglobulin G / blood
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Injections, Intravenous
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Male
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Rats
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Rats, Inbred Lew
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Uveitis / chemically induced
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Uveitis / drug therapy*
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Uveitis / immunology
Substances
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Adjuvants, Immunologic
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Autoantibodies
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Autoantigens
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Free Radical Scavengers
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Glucocorticoids
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Immunoglobulin G
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Allopurinol