Secondary metabolites from Basotho medicinal plants. I. Bulbine narcissifolia

J Nat Prod. 2001 Oct;64(10):1368-72. doi: 10.1021/np010279c.

Abstract

The medicinal plant Bulbine narcissifolia is used by the Basotho, Griqua, and whites of southern Africa for wound healing and as a mild purgative. Extraction of the powdered root has yielded acetosyringone, chrysophanol, knipholone, isoknipholone, 10,7'-bichrysophanol, and chrysalodin in addition to two new anthraquinone glycosides, knipholone-8-O-beta-D-gentiobioside (1) and chrysalodin-10-beta-D-gentiobioside (2). NMR spectroscopy was used to elucidate the structures of 1 and 2 and to show that 1 binds weakly to DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetophenones / chemistry
  • Acetophenones / isolation & purification
  • Anthraquinones / chemistry
  • Anthraquinones / isolation & purification*
  • Chromatography, High Pressure Liquid
  • Circular Dichroism
  • DNA / chemistry
  • Disaccharides / chemistry
  • Disaccharides / isolation & purification*
  • Lesotho
  • Liliaceae / chemistry*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • South Africa
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Stereoisomerism
  • Structure-Activity Relationship
  • Wound Healing

Substances

  • Acetophenones
  • Anthraquinones
  • Disaccharides
  • chrysalodin-10-gentiobioside
  • knipholone
  • knipholone-8-O-gentiobioside
  • acetosyringone
  • DNA
  • chrysophanic acid