Abstract
The medicinal plant Bulbine narcissifolia is used by the Basotho, Griqua, and whites of southern Africa for wound healing and as a mild purgative. Extraction of the powdered root has yielded acetosyringone, chrysophanol, knipholone, isoknipholone, 10,7'-bichrysophanol, and chrysalodin in addition to two new anthraquinone glycosides, knipholone-8-O-beta-D-gentiobioside (1) and chrysalodin-10-beta-D-gentiobioside (2). NMR spectroscopy was used to elucidate the structures of 1 and 2 and to show that 1 binds weakly to DNA.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry
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Acetophenones / isolation & purification
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification*
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Chromatography, High Pressure Liquid
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Circular Dichroism
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DNA / chemistry
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Disaccharides / chemistry
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Disaccharides / isolation & purification*
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Lesotho
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Liliaceae / chemistry*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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South Africa
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Stereoisomerism
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Structure-Activity Relationship
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Wound Healing
Substances
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Acetophenones
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Anthraquinones
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Disaccharides
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chrysalodin-10-gentiobioside
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knipholone
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knipholone-8-O-gentiobioside
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acetosyringone
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DNA
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chrysophanic acid