Isolation and structural determination of DTX-6, a new okadaic acid derivative

B Suárez-Gómez; M L Souto; M Norte; J J Fernández

doi:10.1021/np0100486

Isolation and structural determination of DTX-6, a new okadaic acid derivative

J Nat Prod. 2001 Oct;64(10):1363-4. doi: 10.1021/np0100486.

Authors

B Suárez-Gómez¹, M L Souto, M Norte, J J Fernández

Affiliation

¹ Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain.

PMID: 11678670
DOI: 10.1021/np0100486

Abstract

Diarrhetic shellfish poisoning is an illness caused by toxins accumulated in shellfish and produced by dinoflagellates, mainly of the Dinophysis and Prorocentrum genera. This paper reports the isolation and spectroscopic structural elucidation of a new compound, DTX-6 (2), an ester derivative of okadaic acid (OA) (1), isolated from an artificial culture of strain PLV2 of Prorocentrum lima.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Dinoflagellida / chemistry*
Magnetic Resonance Spectroscopy
Marine Toxins / chemistry
Marine Toxins / isolation & purification*
Marine Toxins / pharmacology
Molecular Structure
Okadaic Acid / analogs & derivatives
Okadaic Acid / chemistry
Okadaic Acid / isolation & purification*
Okadaic Acid / pharmacology
Spectrophotometry, Infrared
Stereoisomerism
Structure-Activity Relationship

Substances

DTX-6 compound
Marine Toxins
Okadaic Acid