Objective: To find and define the effective fraction of Lycopus lucidus on coagulation.
Methods: Method of comparing turbidity, method of cutting a part of the mice tail and method of breaking glass tube.
Results: The two extracted fraction from lycopus lucidus F04-0A and F04-B could inhibit rats platlet aggregation in vitro and mice platelet aggregation in vivo. They could also prolong mice blood coagulation time. However, they had no effect on bleeding time.
Conclusion: Both F04-A and F04-B had effects on inhibiting platelet aggregation and blood coagulation. Moreover, the activity of F04-A was probably stronger than that of F04-B. F04-A may be the effective fraction from Lycopus lucidus on promoting blood circulation and removing blood stasis.