Studies of Australian Ascidians. 5. Virenamides A-C, New Cytotoxic Linear Peptides from the Colonial Didemnid Ascidian Diplosoma virens

Anthony R. Carroll; Yunjiang Feng; Bruce F. Bowden; John C. Coll

doi:10.1021/jo951379o

Studies of Australian Ascidians. 5. Virenamides A-C, New Cytotoxic Linear Peptides from the Colonial Didemnid Ascidian Diplosoma virens

J Org Chem. 1996 Jun 14;61(12):4059-4061. doi: 10.1021/jo951379o.

Authors

Anthony R. Carroll¹, Yunjiang Feng, Bruce F. Bowden, John C. Coll

Affiliation

¹ Chancellery, University of Central Queensland, Rockhampton, Qld. 4702, Australia.

PMID: 11667283
DOI: 10.1021/jo951379o

Abstract

Three new linear cytotoxic tripeptides, virenamides A-C have been isolated from extracts of the Didemnid ascidian Diplosoma virens collected on the Great Barrier Reef, Australia. Their structures were deduced from 1D and 2D NMR spectral data and confirmed by HPLC analysis of the constituent amino acids after hydrolysis of the peptides and derivatization with 1-fluoro-2,4-dinitrophen-5-yl-L-alanine amide using Marfey's procedure.