Use of 2-(tert-butyldiphenylsilyloxymethyl) benzoyl as N-protecting group for the synthesis of prooligonucleotides

T Guerlavais; A Meyer; J L Imbach; F Morvan

doi:10.1016/s0960-894x(01)00515-7

Use of 2-(tert-butyldiphenylsilyloxymethyl) benzoyl as N-protecting group for the synthesis of prooligonucleotides

Bioorg Med Chem Lett. 2001 Nov 5;11(21):2813-6. doi: 10.1016/s0960-894x(01)00515-7.

Authors

T Guerlavais¹, A Meyer, J L Imbach, F Morvan

Affiliation

¹ Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université de Montpellier II, Place E. Bataillon, 34095 Montpellier Cedex 5, France.

PMID: 11597406
DOI: 10.1016/s0960-894x(01)00515-7

Abstract

A short TCCT Me-SATE prooligonucleotide was successfully synthesized using 2-(tert-butyldiphenyloxymethyl) benzoyl protecting group, after its removal by means of trimethylsilyl chloride and water.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Oligonucleotides / chemical synthesis*
Siloxanes / chemistry*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Trimethylsilyl Compounds / chemistry

Substances

2-(tert-butyldiphenylsilyloxymethyl)benzoyl
Oligonucleotides
Siloxanes
Trimethylsilyl Compounds