Isolation and structure elucidation of a new antifungal and antibacterial antibiotic produced by Streptomyces sp. 201

G N Bordoloi; B Kumari; A Guha; M Bordoloi; R N Yadav; M K Roy; T C Bora

doi:10.1271/bbb.65.1856

Isolation and structure elucidation of a new antifungal and antibacterial antibiotic produced by Streptomyces sp. 201

Biosci Biotechnol Biochem. 2001 Aug;65(8):1856-8. doi: 10.1271/bbb.65.1856.

Authors

G N Bordoloi¹, B Kumari, A Guha, M Bordoloi, R N Yadav, M K Roy, T C Bora

Affiliation

¹ Biochemistry Division and Natural Product Chemistry, Regional Research Laboratory (CSIR), Jorhat, Assam, India.

PMID: 11577728
DOI: 10.1271/bbb.65.1856

Abstract

An antibacterial and antifungal antibiotic was isolated from the culture filtrate of Streptomyces sp. 201, and its structure was determined as 2-methyl-heptyl isonicotinate by extensive use of NMR spectroscopy. The compound exhibited marked antimicrobial activity against Bacillus subtilis, Shigella sp., Klebsiella sp., E. coli, Proteus mirabilis, and the pathogenic fungi, Fusarium moniliforme, F. semitectum, F. oxysporum, F. solani and Rhizoctonia solani.

MeSH terms

Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology*
Antitubercular Agents / pharmacology
Bacteria / drug effects
Chromatography, Thin Layer
Fungi / drug effects
Isoniazid / pharmacology
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Streptomyces / chemistry*

Substances

Anti-Bacterial Agents
Antifungal Agents
Antitubercular Agents
Isoniazid