5',6'-dehydroguiachrysine and 5',6'-dehydroguiaflavine, two curarizing quaternary indole alkaloids from the stem bark of Strychnos guianensis

J Penelle; P Christen; J Molgó; M Tits; V Brandt; M Frédérich; L Angenot

doi:10.1016/s0031-9422(01)00255-2

5',6'-dehydroguiachrysine and 5',6'-dehydroguiaflavine, two curarizing quaternary indole alkaloids from the stem bark of Strychnos guianensis

Phytochemistry. 2001 Oct;58(4):619-26. doi: 10.1016/s0031-9422(01)00255-2.

Authors

J Penelle¹, P Christen, J Molgó, M Tits, V Brandt, M Frédérich, L Angenot

Affiliation

¹ Université de Liège, Institut de Pharmacie, Service de Pharmacognosie, CHU, Tour 4, Avenue de l'Hôpital 1, B 4000, Liège, Belgium. jacques.penelle@ulg.ac.be

PMID: 11576611
DOI: 10.1016/s0031-9422(01)00255-2

Abstract

Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of spectral data. Their inhibitory effects on neuromuscular transmission are also reported and compared to that of other quaternary alkaloids.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Indoles / chemistry
Indoles / isolation & purification*
Loganiaceae / chemistry*
Molecular Structure
Plant Stems / chemistry*
Spectrum Analysis

Substances

5',6'-dehydroguiachrysine
5',6'-dehydroguiaflavine
Alkaloids
Indoles