2'-O-modified oligoribonucleotides with terminal 3'-3'-internucleotide linkage and their derivatives

D Novopashina; M Kuznetsova; A Venyaminova

doi:10.1081/NCN-100002456

2'-O-modified oligoribonucleotides with terminal 3'-3'-internucleotide linkage and their derivatives

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):903-7. doi: 10.1081/NCN-100002456.

Authors

D Novopashina¹, M Kuznetsova, A Venyaminova

Affiliation

¹ Novosibirsk State University, ul. Pirogova 2, Novosibirsk 630090, Russia.

PMID: 11563142
DOI: 10.1081/NCN-100002456

Abstract

A high RNA binding affinity and nuclease resistance of 2'-O-modified (2'-O-methyl, 2'-O-tetrahydropyranyl) oligoribonucleotides containing the "inverted" T at the 3'-end have been shown. The synthesis and properties of new photoactivatable perfluoroarylazide derivatives of these oligoribonucleotides are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Kinetics
Oligoribonucleotides, Antisense / chemical synthesis*
Oligoribonucleotides, Antisense / chemistry
Oligoribonucleotides, Antisense / metabolism
Photochemistry
RNA / metabolism

Substances

Oligoribonucleotides, Antisense
RNA