4"-H-TSAO-T, a novel prototype in the HIV-1 specific TSAO family

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):711-4. doi: 10.1081/NCN-100002357.

Abstract

The first TSAO derivative that lacks the amino group at the 3'-spiro moiety has been prepared. This molecule retained its HIV-1 specificity (NNRTI characteristic) but did not select for any of the classical NNRTI-specific mutations in the NNRTI binding pocket, including 138-Lys (TSAO resistant strain).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis*
  • Anti-HIV Agents / pharmacology
  • Deamination
  • HIV Reverse Transcriptase / antagonists & inhibitors
  • HIV Reverse Transcriptase / genetics
  • HIV-1 / drug effects
  • HIV-1 / physiology
  • HIV-2 / drug effects
  • HIV-2 / physiology
  • Humans
  • Mutation
  • Reverse Transcriptase Inhibitors / chemical synthesis*
  • Reverse Transcriptase Inhibitors / pharmacology
  • Spiro Compounds / chemistry*
  • Spiro Compounds / pharmacology
  • Substrate Specificity
  • Thymidine / analogs & derivatives*
  • Thymidine / chemistry*
  • Thymidine / pharmacology
  • Uridine / analogs & derivatives
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors
  • Spiro Compounds
  • HIV Reverse Transcriptase
  • Thymidine
  • TSAO-T
  • Uridine