Resolution of racemic mixtures of carbocyclic analogues of nucleosides and assignment of their absolute configuration

P Besada; C Terán; E Quezada; J M Seco; E Uriarte

doi:10.1081/NCN-100002555

Resolution of racemic mixtures of carbocyclic analogues of nucleosides and assignment of their absolute configuration

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1359-61. doi: 10.1081/NCN-100002555.

Authors

P Besada¹, C Terán, E Quezada, J M Seco, E Uriarte

Affiliation

¹ Departamento de Química Orgánica, Universidad de Vigo, Spain.

PMID: 11563022
DOI: 10.1081/NCN-100002555

Abstract

Racemic trans-6-chloro-9-[2-(hydroxymethyl)cyclopentyl]purine was resolved using HPLC with a chiral column. The absolute configurations of the enantiomers were determined by NMR studies of their (R)- and (S)-methoxyphenylacetates.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromatography, High Pressure Liquid
Nuclear Magnetic Resonance, Biomolecular
Nucleic Acid Conformation
Nucleosides / chemistry
Nucleosides / isolation & purification*
Purines / chemistry
Purines / isolation & purification*
Stereoisomerism

Substances

6-chloro-9-(2(hydroxymethyl)cyclopentyl)purine
Nucleosides
Purines