Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells

N G Moore; F Wang-Johanning; P L Chang; G L Johanning

doi:10.1023/a:1017968029628

Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells

Breast Cancer Res Treat. 2001 Jun;67(3):279-83. doi: 10.1023/a:1017968029628.

Authors

N G Moore¹, F Wang-Johanning, P L Chang, G L Johanning

Affiliation

¹ Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294-3360, USA.

PMID: 11561774
DOI: 10.1023/a:1017968029628

Abstract

We report that 5-day exposure to physiological concentrations of eicosapentaenoic and docosahexaenoic acids resulted in a strong decrease in expression of the RIalpha regulatory subunit of protein kinase A and the PKC-alpha isozyme of protein kinase C in the human breast cancer cell line MDA-MB-231.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arachidonic Acids / pharmacology*
Breast Neoplasms / pathology*
Cyclic AMP-Dependent Protein Kinases / biosynthesis*
Docosahexaenoic Acids / pharmacology*
Female
Gene Expression Regulation, Neoplastic*
Humans
Isoenzymes
Protein Kinase C / biosynthesis*
Tumor Cells, Cultured

Substances

Arachidonic Acids
Isoenzymes
Docosahexaenoic Acids
Cyclic AMP-Dependent Protein Kinases
Protein Kinase C