Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules

K S Ahn; K Y Jung; J H Kim; S R Oh; H K Lee

doi:10.1248/bpb.24.1085

Inhibitory activity of lignan components from the flower buds of Magnoliae fargesii on the expression of cell adhesion molecules

Biol Pharm Bull. 2001 Sep;24(9):1085-7. doi: 10.1248/bpb.24.1085.

Authors

K S Ahn¹, K Y Jung, J H Kim, S R Oh, H K Lee

Affiliation

¹ Immunomodulator Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon.

PMID: 11558575
DOI: 10.1248/bpb.24.1085

Abstract

Inhibitory activity of lignans isolated from Magnoliae fargesii Cheng on cell adhesion molecules on the surface of THP-1 human monocytic cell lines were investigated. Among 16 lignan components tested, six displayed relatively potent inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1).

MeSH terms

Antibodies, Monoclonal / pharmacology
Cell Line
Cell Survival / drug effects
Depression, Chemical
Enzyme-Linked Immunosorbent Assay
Humans
Intercellular Adhesion Molecule-1 / biosynthesis*
Lignans / pharmacology*
Magnoliaceae / chemistry*
Monocytes / drug effects
Monocytes / metabolism
Plant Preparations / pharmacology
Tumor Necrosis Factor-alpha / antagonists & inhibitors
Tumor Necrosis Factor-alpha / pharmacology
Vascular Cell Adhesion Molecule-1 / biosynthesis*

Substances

Antibodies, Monoclonal
Lignans
Plant Preparations
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1