Abstract
A unique cytotoxic metabolite, turbinamide (1), has been isolated from the marine tunicate Sidnyum turbinatum through a bioassay-guided approach. Its structure has been elucidated by an extensive spectroscopic analysis. Turbinamide demonstrated a strong and selective cytotoxic effect against neuronal cells rather than immune system cells. Structure: see text.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemistry
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Alkanes / isolation & purification*
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Alkanes / pharmacology
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Amides / chemistry
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Amides / isolation & purification*
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Amides / pharmacology
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Humans
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Mice
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Monocytes / drug effects
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Neurons / drug effects
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Nuclear Magnetic Resonance, Biomolecular
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Rats
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Tumor Cells, Cultured / drug effects
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Urochordata / chemistry*
Substances
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Alkanes
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Amides
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Antineoplastic Agents
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turbinamide