Turbinamide, a new selective cytotoxic agent from the Mediterranean tunicate Sidnyum turbinatum

Org Lett. 2001 Sep 20;3(19):2941-4. doi: 10.1021/ol016164h.

Abstract

A unique cytotoxic metabolite, turbinamide (1), has been isolated from the marine tunicate Sidnyum turbinatum through a bioassay-guided approach. Its structure has been elucidated by an extensive spectroscopic analysis. Turbinamide demonstrated a strong and selective cytotoxic effect against neuronal cells rather than immune system cells. Structure: see text.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes / chemistry
  • Alkanes / isolation & purification*
  • Alkanes / pharmacology
  • Amides / chemistry
  • Amides / isolation & purification*
  • Amides / pharmacology
  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Humans
  • Mice
  • Monocytes / drug effects
  • Neurons / drug effects
  • Nuclear Magnetic Resonance, Biomolecular
  • Rats
  • Tumor Cells, Cultured / drug effects
  • Urochordata / chemistry*

Substances

  • Alkanes
  • Amides
  • Antineoplastic Agents
  • turbinamide