Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F2t-isoprostane

T Durand; J L Cracowski; A Guy; J C Rossi

doi:10.1016/s0960-894x(01)00473-5

Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F2t-isoprostane

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2495-8. doi: 10.1016/s0960-894x(01)00473-5.

Authors

T Durand¹, J L Cracowski, A Guy, J C Rossi

Affiliation

¹ UMR C.N.R.S. 5074, Université Montpellier 1, Faculté de Pharmacie, 15 Av. C. Flahault, F-34060 Cedex 2, Montpellier, France. froxy@pharma.univ-montp1.fr

PMID: 11549454
DOI: 10.1016/s0960-894x(01)00473-5

Abstract

The total synthesis of the 5-F2t-isoprostane 1 and its 5-epimer 2 from diacetone-D-glucose is described. We report preliminary data on the vascular properties of these compounds.

Publication types

Evaluation Study

MeSH terms

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / pharmacology
Animals
Aorta / drug effects
Biochemistry / methods
In Vitro Techniques
Isomerism
Isoprostanes / chemistry*
Isoprostanes / pharmacology*
Male
Rats
Rats, Wistar
Vasoconstrictor Agents / chemistry*
Vasoconstrictor Agents / pharmacology*

Substances

Isoprostanes
Vasoconstrictor Agents
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid