[Hepatoprotective effect of granules of the dry extract obtained from Gentianopsis barbata (Froel) Ma]

S M Nikolaev; A V Tsyrenzhapov; Z G Sambueva; G G Nikolaeva; G V Ratnikova; L M Tankhaeva

[Hepatoprotective effect of granules of the dry extract obtained from Gentianopsis barbata (Froel) Ma]

Eksp Klin Farmakol. 2001 Jan-Feb;64(1):49-52.

[Article in Russian]

Authors

S M Nikolaev¹, A V Tsyrenzhapov, Z G Sambueva, G G Nikolaeva, G V Ratnikova, L M Tankhaeva

Affiliation

¹ Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Sciences, ul. Sakh'yanova 6, Ulan-Ude, Buryatia, 670047 Russia.

PMID: 11544805

Abstract

The granulated dry extract from Gentianopsis barbata (Froel) Ma in a dose of 0.1 g/kg produced a pronounced therapeutic effect in rats with experimental toxic (tetrachloromethane) and drug-induced (tetracycline) hepatitis. The gentian extract improved the bile production and secretion functions of liver, normalized the protein, lipid, and pigment metabolism, and increased the antioxidant system activity in the test animals.

MeSH terms

Animals
Anti-Bacterial Agents
Carbon Tetrachloride Poisoning / physiopathology
Carbon Tetrachloride Poisoning / prevention & control
Chemical and Drug Induced Liver Injury / etiology
Chemical and Drug Induced Liver Injury / physiopathology
Chemical and Drug Induced Liver Injury / prevention & control*
Female
Liver / drug effects
Liver / metabolism
Liver / physiopathology
Liver Function Tests
Male
Plant Extracts / therapeutic use*
Plants, Medicinal*
Rats
Tetracycline

Substances

Anti-Bacterial Agents
Plant Extracts
Tetracycline